Can I take Lions mane and Matcha together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known harmful interactions between Lion's Mane mushroom and matcha green tea. In fact, many people combine them for a 'balanced' energy boost. However, because both substances can affect the brain and nervous system, some people may feel overly stimulated or experience a mild upset stomach.
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Why this happens
Lion's Mane is thought to stimulate 'nerve growth factor' (NGF) to support brain health, while matcha contains caffeine and L-theanine which improve alertness and focus. There is no evidence that they interfere with how the body absorbs or breaks down the other.
What you should do
It is generally safe to take these together. If you are sensitive to caffeine, monitor for jitters or a racing heart. If you have an upcoming surgery, stop taking Lion's Mane at least two weeks prior as it may slightly thin the blood.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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