Can I take Amitriptyline and Zopiclone together?

You should only take these two medicines together if your doctor is specifically aware you are using both and has told you to do so.

Taking amitriptyline and zopiclone together can make you feel extremely drowsy, dizzy, and confused.

Why this happens

Both medicines work by slowing down the activity in your central nervous system (your brain and nerves).

Amitriptyline is a tricyclic antidepressant with sedative properties, and zopiclone is a 'Z-drug' used for sleep.

When used together, their sedative effects add up (an additive effect), making the overall impact much stronger than taking either medicine alone.

How to know if you're having a drug interaction

You may be experiencing an interaction between amitriptyline and zopiclone if:

• You feel excessively sleepy, drowsy, or sedated during the day.

• You experience confusion, dizziness, or difficulty concentrating.

• You notice trouble with coordination or balance, increasing the risk of falls.

• You have memory problems or unusual behaviour.

• Breathing becomes slower or shallower than usual, especially at night.

• Symptoms appear shortly after taking both medicines together.
  

What you should do

If you have any of the above symptoms, you should:

• Speak to your GP or pharmacist for advice on safe use and dosing.

• Do not stop amitriptyline or zopiclone suddenly unless instructed by a healthcare professional.

• Seek urgent medical help if you experience severe drowsiness, breathing difficulties, or confusion.

• Avoid driving or operating machinery until you know how the combination affects you.

• Tell your healthcare professional about all other medicines and supplements you are taking.

If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or drink any alcohol while using this combination. If you feel excessively sleepy the next day or have trouble breathing, contact your doctor immediately.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.