Can I take Hydroxycobalamin and Mirtazapine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known significant interactions between hydroxocobalamin and mirtazapine. It is generally considered safe to take these two medications together.
In this article:
Continue reading below
Why this happens
Hydroxocobalamin (a form of Vitamin B12) and mirtazapine (an antidepressant) are processed by the body through different pathways. Hydroxocobalamin is a water-soluble vitamin that does not interfere with the liver enzymes responsible for breaking down mirtazapine. Furthermore, they do not have overlapping side effects that would cause concern.
What you should do
You can continue to take both medications as prescribed by your doctor. No special precautions or monitoring are required beyond your usual routine. If you experience any new or unusual symptoms, you should still consult your healthcare provider.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Paracetamol and Ibuprofen together?
There is no harmful interaction between paracetamol and ibuprofen. In fact, they are often taken together because they work in different ways to provide better pain relief than either medicine alone.

Treatment and medication
Can I take Amitriptyline and Zopiclone together?
Taking amitriptyline and zopiclone together can make you feel extremely drowsy, dizzy, and confused. It significantly increases the risk of falling over, especially in the dark or when getting out of bed at night. It can also cause your breathing to become very slow or shallow, and may lead to severe coordination problems.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.