Can I take Paracetamol and Ibuprofen together?

It is safe to take paracetamol and ibuprofen together as long as you follow the recommended doses and don’t have medical conditions that make ibuprofen unsafe (such as stomach ulcers, kidney problems, or certain heart conditions).

How they work

Paracetamol and ibuprofen belong to different classes of painkillers. Paracetamol works mainly in the central nervous system to reduce pain and fever, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain at the site of injury.

Because they are processed by the body differently (paracetamol by the liver and ibuprofen primarily by the kidneys), they do not interfere with each other's absorption or metabolism.

What you should do

It is safe to take paracetamol and ibuprofen at the same time, or you can stagger them (taking one, then the other a few hours later).

• Always follow the dosage instructions on the packaging for each medicine.

• Do not exceed the maximum daily dose for either.

• If you have underlying kidney, liver, or stomach issues, consult your pharmacist or doctor before use.

Important precautions

Asthma

Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Liver disease or high alcohol intake

Taking more than the recommended dose can cause fatal liver damage. Do not take with any other products containing paracetamol (such as cold and flu remedies).

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 28 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Food and drink warnings

Alcohol

While a small amount of alcohol is generally considered safe, chronic heavy drinking or binge drinking increases the risk of liver damage when taking paracetamol. For ibuprofen, alcohol can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake while taking these medicines.

Food (General)

Ibuprofen should ideally be taken with food or a glass of milk. This helps to reduce the risk of stomach upset, indigestion, or irritation to the stomach lining.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.