Can I take Allupurinol and Co-amoxalav together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking allopurinol and co-amoxiclav together increases the risk of developing a skin rash. While most rashes are mild, there is a small risk of a more serious allergic reaction.
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Why this happens
The exact reason isn't fully understood, but allopurinol seems to make the immune system more sensitive to penicillin-type antibiotics like co-amoxiclav. This makes an allergic-style skin reaction more likely to happen.
What you should do
You can take these medicines together if your doctor has prescribed them, but you must be vigilant. If you notice any new skin rash, redness, or itching, contact your doctor immediately. If you develop a rash along with a fever or swelling of the face, seek urgent medical help.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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