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Can I take Maitake and Shiitake together?

Drug interaction guide

Taking maitake and shiitake mushrooms together may increase the risk of bruising or bleeding. Both mushrooms contain natural compounds that can thin the blood and slow down the clotting process. While they are commonly eaten together in food, taking them in concentrated supplement form increases this effect.

For most healthy people eating these mushrooms in normal food amounts, there is no cause for concern. However, if you are taking concentrated supplements, you should be cautious.

Stop taking these supplements at least two weeks before any scheduled surgery.

If you are already taking blood-thinning medications (such as warfarin or aspirin), speak to your doctor before combining these supplements.

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How to know if you're having a drug interaction

You may be experiencing an interaction between maitake and shiitake mushrooms if:

  • You took large amounts of both together (especially as supplements).

  • You feel sick (nausea), have diarrhoea, or an upset stomach.

  • You feel dizzy or weak, especially if you have diabetes (they can lower blood sugar).

  • You notice easy bruising or bleeding (they may affect blood clotting).

  • You develop rash, itching, or breathing problems (possible allergy).

What you should do

If you have any of the above symptoms, you should:

  • Stop taking the mushrooms or supplements.

  • Avoid taking both together unless a healthcare professional advises it.

  • Get urgent help for breathing problems, severe allergic reaction, or heavy bleeding.

  • Speak to a GP or pharmacist if symptoms are mild but don’t go away.

  • Monitor blood sugar if you have diabetes.

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Why this happens

Both maitake and shiitake mushrooms have 'antiplatelet' properties. This means they make the tiny cells in your blood (platelets) less 'sticky', which makes it harder for your blood to form clots. When used together, this effect can be stronger.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together.

Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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