Can I take Lions mane and Royal sun together?
Drug interaction guide
Originally published 25 Jan 2026
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Both Lion's Mane (Hericium erinaceus) and Royal Sun (Agaricus blazei) may have mild blood-thinning effects and can lower blood sugar levels. Taking them together might increase the risk of bruising or bleeding, and could potentially cause your blood sugar to drop lower than expected.
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Why this happens
Both fungi contain compounds that may interfere with blood clotting (anti-platelet activity) and improve insulin sensitivity. When combined, these effects can be additive, meaning they reinforce each other.
What you should do
This combination is usually fine for healthy individuals, but you should use caution if you are already taking blood-thinning medications (like aspirin or warfarin) or diabetes medication. Monitor your blood sugar levels if you are diabetic, and watch for signs of easy bruising or prolonged bleeding from small cuts. If you have a scheduled surgery, stop taking both supplements at least two times weeks beforehand.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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