Can I take Ibuprofen gel 10% and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no harmful interaction between ibuprofen gel and paracetamol. In fact, they are often used together to provide better pain relief than using either one alone.
In this article:
Continue reading below
Why this happens
Paracetamol and ibuprofen work in different ways to block pain signals. Because the ibuprofen is applied as a gel to the skin, very little of it enters your bloodstream compared to a tablet, which further reduces the risk of any side effects.
What you should do
It is safe to use these two medicines at the same time. Always follow the dosage instructions on the packaging for both products. If your pain does not improve after using both, speak to a pharmacist or doctor.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Maitake and Shiitake together?
Taking maitake and shiitake mushrooms together may increase the risk of bruising or bleeding. Both mushrooms contain natural compounds that can thin the blood and slow down the clotting process. While they are commonly eaten together in food, taking them in concentrated supplement form increases this effect.

Treatment and medication
Can I take Bactrim and Venlafaxine dexcel together?
Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. It can also lead to an imbalance of salts in your blood (low sodium) and, in some cases, may affect your heart rhythm.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.