Can I take Danazol and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking danazol and tramadol together can increase the amount of tramadol in your bloodstream. This makes you much more likely to experience serious side effects, such as extreme sleepiness, breathing difficulties, and a rare but dangerous condition called serotonin syndrome (which causes confusion, sweating, and shaking). It may also increase the risk of having a seizure.
In this article:
Continue reading below
Why this happens
Tramadol is broken down in the liver by specific enzymes. Danazol blocks these enzymes, preventing the body from clearing the tramadol. This leads to a build-up of the painkiller to potentially toxic levels.
What you should do
You should speak to your doctor before taking these two medicines together. Your doctor may need to adjust your dose of tramadol or monitor you more closely for side effects. If you feel unusually dizzy, sleepy, or have trouble breathing, seek medical help immediately.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Ibuprofen and Naproxen together?
Taking ibuprofen and naproxen together significantly increases your risk of serious side effects, particularly stomach ulcers, internal bleeding, and kidney problems. It can also make your blood pressure rise and cause fluid retention.
Treatment and medication
Can I take Maitake and Shiitake together?
Taking maitake and shiitake mushrooms together may increase the risk of bruising or bleeding. Both mushrooms contain natural compounds that can thin the blood and slow down the clotting process. While they are commonly eaten together in food, taking them in concentrated supplement form increases this effect.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.