Can I take Colecalciferol and Tizanidine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between colecalciferol and tizanidine. It is generally considered safe to take these two medications together.
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Why this happens
Colecalciferol (Vitamin D3) is a fat-soluble vitamin processed primarily by the liver and kidneys to help the body absorb calcium. Tizanidine is a muscle relaxant that works on the central nervous system and is mainly broken down by a specific liver enzyme (CYP1A2). Because they use different pathways in the body and have different targets, they do not interfere with each other's effectiveness or safety.
What you should do
You can continue to take both medications as prescribed by your doctor. As with any medication, if you notice any unusual side effects, you should mention them to your healthcare provider.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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