Can I take Bisoprolol and Empagliflozin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can increase the risk of your blood pressure dropping too low (hypotension) or your blood sugar levels falling too low (hypoglycaemia). Additionally, bisoprolol can sometimes hide the warning signs of low blood sugar, such as a fast heartbeat or tremors.
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Why this happens
Both medicines can lower blood pressure: bisoprolol slows the heart rate, while empagliflozin acts as a diuretic (water pill) which reduces fluid in the body. Furthermore, while empagliflozin lowers blood sugar, bisoprolol (a beta-blocker) can interfere with the body's natural response to low sugar and mask symptoms like palpitations.
What you should do
You can usually take these medicines together, but you should monitor your blood pressure and blood sugar levels more closely, especially when starting or changing doses. Be aware that you might not feel the usual 'racing heart' if your sugar drops, so look out for other signs like sweating or hunger. If you feel dizzy, lightheaded, or faint, contact your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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