Can I take Amlopadine and Atorvastatin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a more serious muscle breakdown called rhabdomyolysis.
In this article:
Amlodipine and atorvastatin can usually be taken together safely and it is very common for these two medicines to be prescribed together. However, taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood.
Amlodipine can slow down the liver enzyme (CYP3A4) that is responsible for breaking down atorvastatin. Because the body processes the statin more slowly, the levels of the medicine build up in your system.
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How to know if you're having a drug interaction?
You may be experiencing an interaction between amlodipine and atorvastatin if you experience:
Muscle pain, weakness, or cramps.
Dark-coloured pee.
Unexplained fatigue.
Yellowing of the skin or eyes (jaundice).
Stomach pain or feeling sick (nausea).
These could indicate that atorvastatin levels are higher than normal or affecting your liver or muscles.
What you should do
If you notice these symptoms, you should:
Contact your doctor immediately-don’t wait for the next appointment.
Do not stop your medications on your own unless your doctor tells you to.
Report all symptoms in detail, including when they started and how severe they are.
Attend any recommended blood tests to check liver function and muscle enzymes.
This helps your doctor decide if your dose needs adjusting or if an alternative treatment is safer.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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