Can I take Vitamin b12 and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known negative interaction between Vitamin B12 and Vitamin D. In fact, they are often taken together to support overall health.
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Why this happens
These two vitamins are processed by the body through different pathways. Vitamin B12 is a water-soluble vitamin absorbed mainly in the small intestine with the help of a protein called intrinsic factor. Vitamin D is a fat-soluble vitamin that requires dietary fat for absorption. They do not compete for absorption or interfere with how the other is broken down or used by the body.
What you should do
It is safe to take Vitamin B12 and Vitamin D at the same time. You do not need to space them apart. For best results, Vitamin D should be taken with a meal containing some fat (like yoghurt, eggs, or avocado) to help your body absorb it properly. Always follow the dosage instructions on the label or those provided by your healthcare professional.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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