Can I take Sertraline and Tizanidine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can cause your blood pressure to drop too low and may make you feel very sleepy or dizzy. It can also increase the risk of a rare but serious condition called serotonin syndrome, which affects your nervous system.
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Why this happens
Both drugs can lower blood pressure and cause drowsiness (additive effect). Additionally, sertraline can slightly interfere with how the liver breaks down tizanidine, and both drugs influence serotonin levels in the brain.
What you should do
Speak to your doctor before taking these together. If you are already taking both, do not stop suddenly, but watch out for extreme dizziness, fainting, confusion, or shivering. Your doctor may need to adjust your dose.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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