Can I take Fexofenadine and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Both fexofenadine and pregabalin can cause drowsiness, dizziness, and blurred vision. Taking them together may increase these side effects, making you feel more tired or less alert than usual.
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Why this happens
This is an 'additive' effect. While fexofenadine is a non-drowsy antihistamine, it can still cause mild sleepiness in some people. Pregabalin commonly affects the central nervous system. When combined, their individual effects on your alertness can add together.
What you should do
It is generally safe to take these together, but you should be cautious when you first start the combination. See how they affect you before driving or using machinery. If you feel very drowsy or dizzy, speak to your pharmacist or doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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