Can I take Esomeprazole and Indapamide together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can lead to low levels of magnesium and potassium in your blood. This is more likely to happen if you take them together for a long time (usually more than three months). Low levels of these minerals can cause symptoms like tiredness, muscle cramps, or an irregular heartbeat.
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Why this happens
Indapamide is a 'water pill' (diuretic) that helps your body get rid of excess salt and water, but it also causes you to lose potassium and magnesium through your urine. Esomeprazole is a proton pump inhibitor (PPI) that can reduce the amount of magnesium your body absorbs from food. When used together, these effects can add up, leading to a deficiency.
What you should do
You can take these medicines together, but your doctor may want to monitor your mineral levels with occasional blood tests. If you experience unusual muscle weakness, spasms, or a fluttering feeling in your chest (palpitations), you should contact your doctor. Do not stop taking your medication without speaking to a healthcare professional first.
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Important precautions
Sulphonamide allergy
Do not take this medicine if you have a known allergy to sulphonamide antibiotics (such as sulfamethoxazole), as you may have a similar allergic reaction to indapamide.
Low potassium (Hypokalaemia)
This medicine lowers potassium levels in your blood. You must have regular blood tests, as low potassium can cause serious heart rhythm problems, especially if you also take digoxin.
Severe diarrhoea
If you develop severe, watery, or persistent diarrhoea, contact your doctor immediately. This medicine can increase your risk of a serious bowel infection called Clostridium difficile.
Food and drink warnings
Alcohol
Drinking alcohol while taking indapamide may increase the medicine's blood-pressure-lowering effect. This can make you feel dizzy, lightheaded, or faint, especially when standing up quickly. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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