Can I take Black cohosh and Vitamin b12 together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known interactions between black cohosh and vitamin B12. It is generally considered safe to take these two supplements together.
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Why this happens
Black cohosh and vitamin B12 are processed by the body through different pathways. Black cohosh is primarily broken down by the liver, while vitamin B12 is absorbed in the small intestine and does not interfere with the liver enzymes that process black cohosh. They do not have overlapping effects on the body's systems.
What you should do
You can continue to take both supplements as directed. However, always inform your doctor or pharmacist about all the supplements you are taking, especially if you have a history of liver problems, as black cohosh has been rarely linked to liver issues.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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